You cannot directly UEFI-boot to the E2B Menu system.
You must first convert a UEFI-bootable payload to a FAT32 .imgPTN file - see here for details.
This is the recommended and most compatible way to boot via UEFI (and works for MBR booting too).
It also supports Secure Boot (if the boot files in your payload are signed).
You can convert UEFI-bootable ISO files or single-partition USB drives to an .imgPTN file. You then copy the .imgPTN file to the E2B USB drive. The .imgPTN image file will then be 'switched-in' to completely replace the E2B partition with a FAT32 partition. You can then UEFI-boot (or MBR-boot) to the new payload files on the new 'switched-in' FAT32 partition.
The process is:
1. First convert the ISO (or other payload) to a .imgPTN file using the MPI Tool Kit (drag-and-drop onto Deskrop shortcut) and then copy the .imgPTN to your E2B USB drive.
2. Run \MAKE_THIS_DRIVE_CONTIGUOUS.cmd to make the .imgPTN file contiguous on the USB drive.
3. MBR-boot and select the .imgPTN file from the menu - OR - run \_ISO\SWITCH_E2B.exe and double-click on the .imgPTN file. The E2B drive will now contain a completely different partition which will contain your EFI files.
4. Now you can UEFI-boot (or MBR-boot) from the E2B USB drive.
5. When finished, restore the E2B drive partition by MBR-booting to the E2B CSM menu and selecting menu #0 - OR - use \e2b\SWITCH_E2B.exe to restore the E2B partition - OR - use one of the .cmd scripts in the \e2b folder under Windows to restore the E2B partition.
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Other methods of UEFI-booting
These methods all have disadvantages. You may not be able to boot from all systems, Secure Boot may not work, etc.
Use the E2B grub2 menu system (for linux payloads)
You can add a grub2 menu system to E2B. This is most suitable for USB Hard Disks. The menu system has the advantage that you may be able to UEFI-boot to some payloads which do not normally support UEFI-booting, however for Windows-based payloads, always use a .imgPTN file.
Secure boot for memtest86 is supported - it is also possible to secure boot to some linux payloads (but you will need to use MokManager which will alter the NVRAM of the BIOS in the system that you are booting from).
Add the UEFI boot files directly onto the E2B drive (not recommended)
If your E2B USB drive is formatted as FAT32 you can add UEFI boot files to the USB drive and then UEFI-boot directly from the E2B USB drive.
WARNING: Adding the UEFI boot add-on may prevent some systems from booting to the E2B menu! For this reason, I strongly recommend you use separate .imgPTN files for each UEFI payload and do not use this method.
For instance, you could add a dual-boot version of Win8.1SE (WinPE) to the E2B USB drive so that you could boot to WinPE either via MBR booting (if you add a bootmgr .mnu file) or via UEFI booting from either a 32-bit or 64-bit system.
By adding the rEFInd boot manager, you can boot to a variety of different UEFI (.EFI) boot files.
Then, if you UEFI-boot from the E2B drive, you will get a rEFInd GUI icon menu and you can choose to UEFI-boot to Windows, KonBoot or Memtest86.
If you use the rEFInd boot manager, secure booting will not be supported however.
The E2B_UEFI_BOOT_ADDON.zip download is available on the Alternate Downloads site and uses rEFInd as a boot manager. Extract the files to a folder on your system and read the rEFInd_READ_ME.txt file for instructions.
Note: It is not possible to add more than one instance of the same OS, unless each one uses a different folder or file structure.